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胚胎時差培養箱Embryoscope基於其強大的決策支持工具KID Score D3和KID Score D5模型，通過胚胎的形態學及形態動力學，對胚胎進行篩選評分，選擇優質的胚胎進行冷凍或者移植。胚胎形態學包括多核化，細胞碎片化，細胞分裂均勻度等，其中囊胚的形態學是KID Score D5模型中的重要指標，主要通過評估囊胚的擴張程度（發育速度），卵裂形態和碎片等情況可初步篩選出相對優質的囊胚，下文即為基於囊胚的形態學（擴張程度）與其整倍性，妊娠率等的相關性研究：
Blastocyst contractions are strongly related with aneuploidy, lower implantation rates and slower embryo cleavage timing: time lapse study
E Gazzo1, F Peña1, F Valdéz2, A Chung1, M Velit1, M Ascenzo1, E Escudero1
1Clínica de Fertilidad INMATER, Lima, Peru. 2Genomics Peru, Lima, Peru.
Objectives: We set out to identify contraction (CT) patterns in human blastocyst and their correlation with their ploidy status (PGT-A analysis), the time they took to reach blastocyst and the pregnancy rate.
Methods: Design: Retrospective study. 912 embryos from 270 patients that went through our center were evaluated. All embryos were cultivated in the Embryoscope incubator. From 912 embryos that started the cohort, 778 were tested for aneuploidy using an NGS platform in a reference laboratory. Blastocyst contractions (CT) were evaluated using the "embryo drawing tool" to obtain the CT percentage. 182 SET were performed, and the mean patient age was 30.44 years, ranging from 24 to 39 years.
Results: Embryos was divided in two groups, those that contracted (CT) and those that did not, we call them "solo expanding" (SE). When this was compared to ploidy status the embryos that SE showed 58.33% to be euploid while 53.58% of embryos that CT where aneuploid. This was statistically significant (p=0.029) showing that embryos that don't contract SE have higher chances of being euploid that embryos that contract CT. When we compared pregnancy rates, we also saw an increase in embryos that SE (63.10%) with embryos that CT (46.67%), this was also statistically significant (p=0.012). Finally, we saw that embryos that CT take longer to reach blastocyst stage compared to SE embryos. This also was significant (p=0.004). Finally we evaluated if the patients age an impact on whether the embryo was CT or SE and found no difference, showing that age should not be a factor y embryo contraction.
Conclusion: The results in this study show statistically significance in two analyzed traits. We showed that CT embryos show a higher chance of being aneuploid, and that they have a lower implantation rate. Also, we showed that embryos that CT take longer to reach blastocyst stage. All this was showed to happen regardless of maternal age. This proves that looking for embryo contractions could be helpful for selecting an embryo for transfer.